The Louisville Cardinals will once again be big time underdogs when they take the field on Friday night.

Per VegasInsider.com, the Cards are 21-point underdogs for their week ten match-up at Syracuse.

Cuse is the only team from the Atlantic division that hasn’t beaten Louisville since the Cards joined the ACC in 2014. Given that this is the best Syracuse team in quite some time, that will likely change on Friday night.

Dino Babers is having his best season yet in year three. The Orange are 7-2 overall and they’re ranked 12th in the AP Poll.

As for Louisville, the Cards are now 1-7 against the spread this season.

Date Opponent Closing Line Total Result ATS
Sep 1 Alabama 24 61 Lost  14 – 51 Loss
Sep 8 Indiana State -42 68.5 Won  31 – 7 Loss  /  Under
Sep 15 WKU -23.5 54 Won  20 – 17 Loss  /  Under
Sep 22 Virginia 4.5 53 Lost  3 – 27 Loss  /  Under
Sep 29 Florida State 5 47 Lost  24 – 28 Win  /  Over
Oct 5 Georgia Tech 5.5 56.5 Lost  31 – 66 Loss  /  Over
Oct 13 Boston College 12 57 Lost  20 – 38 Loss  /  Over
Oct 27 Wake Forest -3 68 Lost  35 – 56 Loss  /  Over
Nov 3 Clemson 39 61 Lost  16 – 77 Loss  /  Over

Louisville is tied for dead last among the 130 FBS college football program when it comes to covering the spread.

t129. Louisville 1-8 ATS
t129. Navy 1-8 ATS
128. Connecticut 1-7-1 ATS
t126. Washington 2-8 ATS
t126. New Mexico St 2-8 ATS
t120. 6 teams tied at 2-7 ATS (SD State, South Florida, Wisconsin, Florida Atlantic, TCU, Wake Forest

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