The Cardinals defeated the Boston College Eagles, 41-39. Louisville amassed over 600 yards of total offense. Cardinals quarterback Micale Cunningham threw for 288 yards and was responsible for 2 touchdowns. Javian Hawkins rushed for 172 yards and a score and Louisville had 3 100-yard receivers led by Seth Dawkins who had 170 yards and a touchdown. Boston College backup quarterback Dennis Grosel came in for the injured Anthony Brown and passed for 3 touchdowns.